Irina Petrache Selected Research

Hypoxia (Hypoxemia)

1/2021	Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function.
1/2020	Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension.
1/2018	Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.
4/2015	Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure.
7/2012	LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension.
11/2011	Dihydroceramide-based response to hypoxia.

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Irina Petrache Research Topics

Disease

45	Emphysema 01/2022 - 11/2004
21	Chronic Obstructive Pulmonary Disease (COPD) 03/2021 - 11/2004
20	Inflammation (Inflammations) 07/2021 - 11/2004
14	Lung Injury 01/2020 - 07/2008
11	Pneumonia (Pneumonitis) 01/2021 - 11/2004
9	Lung Diseases (Lung Disease) 01/2021 - 10/2008
8	Pulmonary Hypertension 01/2020 - 05/2012
6	Hypoxia (Hypoxemia) 01/2021 - 11/2011
5	Infections 01/2022 - 01/2016
4	Asthma (Bronchial Asthma) 01/2021 - 04/2011
4	Neoplasms (Cancer) 10/2017 - 10/2008
3	Acute Lung Injury 12/2021 - 05/2003
3	Fibrosis (Cirrhosis) 01/2021 - 01/2016
3	Wounds and Injuries (Trauma) 01/2020 - 11/2006
3	Airway Obstruction (Choking) 01/2020 - 01/2013
3	Pulmonary Emphysema 01/2018 - 10/2006
3	Pain (Aches) 07/2014 - 04/2009
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 01/2021
2	COVID-19 01/2021 - 01/2021
2	Chronic Bronchitis 12/2020 - 01/2013
2	Endotoxemia 03/2019 - 06/2014
2	Sepsis (Septicemia) 01/2018 - 06/2014
2	Necrosis 10/2017 - 07/2015
2	Hypertrophy 01/2017 - 06/2015
2	Vascular Remodeling 01/2016 - 05/2012
2	Cystic Fibrosis (Mucoviscidosis) 01/2015 - 09/2009
2	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2013 - 01/2009
2	Pulmonary Edema 11/2011 - 05/2003
2	Pathologic Processes 11/2011 - 11/2010
1	Human Influenza (Influenza) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Post-Acute COVID-19 Syndrome 01/2022
1	Niemann-Pick Diseases (Niemann Pick Disease) 01/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021

Drug/Important Bio-Agent (IBA)

34	SmokeIBA 01/2022 - 11/2004
21	CeramidesIBA 01/2022 - 05/2005
14	SphingolipidsIBA 01/2022 - 08/2006
10	Proteins (Proteins, Gene)FDA Link 07/2021 - 10/2008
9	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 11/2004
8	EnzymesIBA 01/2021 - 05/2005
6	CytokinesIBA 01/2022 - 05/2003
6	Pancreatic Elastase (Elastase)IBA 07/2021 - 08/2015
4	Protease Inhibitors (Protease Inhibitor)IBA 01/2016 - 11/2004
4	Caspase 3 (Caspase-3)IBA 01/2013 - 10/2006
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2012 - 05/2005
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2011 - 05/2005
3	Phosphates (Orthophosphate)IBA 01/2022 - 01/2016
3	AntioxidantsIBA 01/2020 - 11/2004
3	Hyaluronic Acid (Hyaluronan)IBA 01/2020 - 01/2018
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2019 - 05/2003
3	LipopolysaccharidesIBA 03/2019 - 02/2015
3	Neutralizing AntibodiesIBA 01/2019 - 10/2009
3	Biomarkers (Surrogate Marker)IBA 01/2016 - 01/2013
3	member 1 small inducible cytokine subfamily EIBA 02/2014 - 10/2009
3	Environmental Pollutants (Pollutants, Environmental)IBA 08/2012 - 11/2006
3	SerpinsIBA 05/2012 - 06/2006
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2022 - 07/2014
2	SphingomyelinsIBA 03/2021 - 02/2015
2	sphingosine kinaseIBA 01/2021 - 01/2016
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2021 - 01/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 10/2017
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2014
2	AcidsIBA 01/2021 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 06/2015
2	Nicotine FDA Link 01/2020 - 07/2015
2	Superoxide DismutaseIBA 01/2020 - 07/2008
2	GlycosphingolipidsIBA 11/2019 - 02/2015
2	P-2 (P 2)IBA 07/2019 - 06/2015
2	inter-alpha-inhibitorIBA 03/2019 - 01/2018
2	Blood Proteins (Serum Proteins)IBA 03/2019 - 01/2018
2	AntibodiesIBA 01/2019 - 10/2009
2	Biological ProductsIBA 11/2018 - 06/2006
2	Estrogen ReceptorsIBA 01/2018 - 05/2012
2	Messenger RNA (mRNA)IBA 01/2018 - 11/2014
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2017 - 06/2015
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2017 - 07/2013
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2016 - 02/2010
2	Oxygen (Dioxygen)IBA 04/2015 - 11/2011
2	Conditioned Culture MediaIBA 02/2015 - 01/2011
2	CaspasesIBA 10/2014 - 07/2008
2	Small Interfering RNA (siRNA)IBA 01/2013 - 11/2011
2	NF-kappa B (NF-kB)IBA 07/2010 - 10/2008
2	Opiate AlkaloidsIBA 09/2009 - 04/2009
2	Morphine (MS Contin)FDA LinkGeneric 09/2009 - 04/2009
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Interleukin-8 (Interleukin 8)IBA 01/2022
1	E-Cigarette VaporIBA 01/2022
1	MTOR InhibitorsIBA 12/2021
1	Immunoglobulin G (IgG)IBA 07/2021
1	Phosphatidylethanolamines (Cephalins)IBA 03/2021
1	CollagenIBA 01/2021
1	neodymium pyrocatechin disulfonate (NPD)IBA 01/2021
1	clonidine-displacing substance (ClDS)IBA 01/2021
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021

Therapy/Procedure

9	Therapeutics 03/2021 - 05/2005
2	Drug Therapy (Chemotherapy) 07/2014 - 10/2008